Table 3.
ACCENT elderly 5-year survival rates (%) and Adjuvant! Online predictions assuming either “average for age” or “minor” comorbidities. Median predictions within corresponding Kaplan-Meier 95% confidence intervals and absolute differences less than 5% are shown in bold.
| N | K-M | 95% CI | Average for Age Comorbidities Assumed | Minor Comorbidities Assumed | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A!O Pred | Delta (O–E) | % Agree | Sens | Spec | A!O Pred | Delta (O–E) | % Agree | Sens | Spec | ||||
| Overall | 2967 | 65 | (63, 66) | 58 | 7 | 65 | 82 | 40 | 64 | 1 | 65 | 89 | 29 |
| Age | |||||||||||||
| 70–74 | 1944 | 67 | (65, 69) | 61 | 6 | 67 | 88 | 31 | 65 | 2 | 67 | 91 | 25 |
| 75+ | 1023 | 61 | (58, 64) | 53 | 8 | 63 | 70 | 54 | 59 | 2 | 61 | 84 | 34 |
| Sex | |||||||||||||
| Male | 1569 | 63 | (61, 66) | 56 | 7 | 63 | 77 | 43 | 62 | 1 | 63 | 87 | 30 |
| Female | 1398 | 66 | (64, 69) | 62 | 4 | 68 | 88 | 36 | 66 | 0 | 67 | 91 | 27 |
| TStage | |||||||||||||
| T1 | 83 | 84 | (77, 92) | 74 | 10 | 83 | 100 | 8 | 79 | 5 | 81 | 100 | 0 |
| T2 | 441 | 67 | (63, 72) | 68 | −1 | 63 | 98 | 9 | 74 | −7 | 63 | 99 | 5 |
| T3 | 2062 | 66 | (64, 68) | 57 | 9 | 65 | 82 | 38 | 63 | 3 | 65 | 90 | 26 |
| T4 | 381 | 49 | (45, 55) | 46 | 3 | 66 | 57 | 72 | 51 | −2 | 64 | 66 | 61 |
| Grade | |||||||||||||
| 1 | 278 | 68 | (63, 74) | 61 | 7 | 65 | 86 | 29 | 65 | 3 | 66 | 93 | 20 |
| 2 | 1950 | 66 | (64, 68) | 60 | 6 | 65 | 86 | 31 | 65 | 1 | 65 | 92 | 21 |
| 3+ | 739 | 59 | (56, 63) | 53 | 6 | 66 | 70 | 63 | 57 | 2 | 65 | 79 | 48 |
| + Node | |||||||||||||
| 1–3 | 1899 | 72 | (70, 74) | 63 | 9 | 69 | 94 | 15 | 68 | 4 | 69 | 99 | 6 |
| 4–10 | 937 | 54 | (51, 58) | 50 | 4 | 57 | 56 | 59 | 54 | 0 | 56 | 69 | 43 |
| > 10 | 131 | 31 | (24, 40) | 31 | 0 | 70 | 0 | 98 | 32 | −1 | 79 | 0 | 100 |
| # Node | |||||||||||||
| 1–3 | 127 | 72 | (64, 80) | 53 | 19 | 65 | 74 | 48 | 58 | 14 | 73 | 91 | 38 |
| 4–10 | 985 | 61 | (58, 64) | 58 | 3 | 64 | 79 | 44 | 63 | −2 | 63 | 85 | 34 |
| > 10 | 1855 | 66 | (64, 69) | 59 | 7 | 66 | 85 | 37 | 64 | 2 | 66 | 91 | 25 |
| Adj Rx | |||||||||||||
| 5FU/LV | 1814 | 62 | (60, 64) | 58 | 4 | 63 | 81 | 40 | 63 | −1 | 63 | 88 | 30 |
| + Ox | 1153 | 69 | (67, 72) | 60 | 9 | 69 | 85 | 39 | 65 | 4 | 69 | 92 | 26 |
| Decade | |||||||||||||
| 1980s | 211 | 51 | (45, 59) | 66 | −15 | 49 | 95 | 14 | 72 | −21 | 46 | 95 | 9 |
| 1990s | 1349 | 62 | (60, 65) | 57 | 5 | 64 | 80 | 44 | 62 | 0 | 64 | 87 | 34 |
| 2000s | 1407 | 69 | (67, 72) | 59 | 10 | 69 | 84 | 41 | 64 | 5 | 69 | 91 | 27 |
Abbreviations: TStage, tumor stage; +Node, positive nodes; # Node, nodes examined; Adj Rx, adjuvant chemotherapy; K-M, Kaplan-Meier; CI, confidence interval, Pred, median prediction; Diff, difference; O, observed; E, expected; Agree, agreement; Sens, sensitivity; Spec, specificity.