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. 2016 Jul 7;226:142–151. doi: 10.1016/j.virusres.2016.07.003

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© 2016 Elsevier B.V. All rights reserved.

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Fig. 3 — Scheme of ORF3 encoded protein in different cell-adapted CoVs. Genus-specific ORF3-encoded protein is shown for: (i) HCoV-229E clinical isolate J0304 (HCoV, GenBank JX503061), and for cell-adapted viruses VR-740 (HCoVca1, AF304460) and HC-LP (HCoVca2, EF198671), upper scheme; (ii) PEDV virulent DR13 (JQ023161) and attenuated DR13 (PEDVca, JQ023162), middle scheme; and (iii) TGEV virulent Miller (DQ811785) and attenuated M60 (TGEVca, DQ811786), lower scheme. Predicted transmembrane domains (TM) are indicated in all cases. Mutations leading to a reduction in sequence identity are indicated in green and light blue.