Table 1.
Characteristics of colorectal cancer cases diagnosed nationwide (2007-2011) according to time from index colonoscopy to diagnosis (N=10,365).a
| Tumor/patient characteristics | Diagnostic colonoscopy CRC | Post-colonoscopy CRC (N=725) by interval from index colonoscopy to CRC diagnosise | |||
|---|---|---|---|---|---|
|
| |||||
| <3y | <5y | <10y | ≥10y | ||
|
| |||||
| Number of cases | 9640 | 243 | 373 | 566 | 159 |
|
| |||||
| Age at CRC diagnosis (years) mean ± SD | 69.8 ± 11.1 | 73.5 ± 10.7 | 73.2 ± 10.4 | 73.8 ± 10.3 | 73.3 ± 11.5 |
|
| |||||
| Gender | |||||
| Male, N (%) | 5132 (53.2) | 131 (53.9) | 187 (50.1) | 261 (46.1) | 66 (41.5) |
| Female, N (%) | 4508 (46.8) | 112 (46.1) | 186 (49.9) | 305 (53.9) | 93 (58.5) |
|
| |||||
| Inflammatory Bowel Disease, N (%) | 56 (0.6) | 18 (7.4) | 31 (8.3) | 55 (9.7) | 16 (10.1) |
|
| |||||
| Tumor locationb | |||||
| Proximal, N (%) | 2948 (30.6) | 136 (56.0) | 200 (53.6) | 306 (54.1) | 80 (50.3) |
| Distal, N (%) | 6379 (66.2) | 89 (36.6) | 151 (40.5) | 233 (41.2) | 71 (44.7) |
|
| |||||
| Stagec | |||||
| Localized, N (%) | 3833 (39.8) | 104 (42.8) | 165 (44.2) | 253 (44.7) | 79 (49.7) |
| Regional, N (%) | 2995 (31.1) | 69 (28.4) | 106 (28.4) | 167 (29.5) | 45 (28.3) |
| Metastatic, N (%) | 1414 (14.7) | 29 (11.9) | 42 (11.3) | 62 (11.0) | 21 (13.2) |
|
| |||||
| MMR Statusd | |||||
| Proficient, N (%) | 6952 (72.1) | 150 (61.7) | 232 (62.2) | 341 (60.2) | 107 (67.3) |
| Deficient (Loss), N (%) | 1385 (14.4) | 59 (24.3) | 92 (24.7) | 150 (26.5) | 30 (18.9) |
| Absent MLH1 | 1190 (12.3) | 54 (22.2) | 82 (22.0) | 135 (23.9) | 25 (15.7) |
| Absent MSH2 | 127 (1.3) | 7 (2.9) | 9 (2.4) | 11 (1.9) | 3 (1.9) |
| Absent MSH6 only | 80 (0.8) | 0 | 2 (0.5) | 5 (0.9) | 3 (1.9) |
| Absent PMS2 only | 20 (0.2) | 0 | 1(0.3) | 1(0.2) | 0 |
a
Data restricted to 10,365 cases evaluated at 12 Danish institutes performing immunohistochemical testing for MMR proteins on >75% of CRC tumors, 2007-2011.
b
Unknown,tumor location: DC cases: 313 (3.2%); PC cases: 35 (4.8%).
c
Unknown stage: DC cases: 1398 (14.5%); PC cases: 98 (13.5%).
d
Not tested: DC cases: 1303 (13.5%); PC cases: 97 (13.4%).
e
Only tumors diagnosed > 180 days after index colonoscopy were included as PC cases. See Methods for details