Table 2.

Multivariate analysis of factors independently associated with post-colonoscopy colorectal cancer between 180 days and 10 years after index colonoscopy (n = 566 PC cases).

Patient or tumor characteristic	PC cases 3 - 6 years mean ± SD or n (%)	PC cases 180 days - 10 years mean ± SD or n (%)	3 - 6 years OR (95% CI)	180 days - 10 years OR (95% CI)
Age at CRC diagnosis (years)	73.2 ± 9.9	73.8 ± 10.3	1.02 (1.01, 1.04)	1.03 (1.02, 1.04)
Female sex	116 (59.8)	305 (53.9)	0.74 (0.54, 1.02)	0.91 (0.75, 1.10)
Proximal tumor location	104 (53.6)	306 (54.1)	1.92 (1.36, 2.72)	2.33 (1.89, 2.88)
Metastatic at presentation	21 (10.8)	62 (11.0)	0.68 (0.41, 1.13)	0.66 (0.48, 0.90)
Mismatch repair-deficient
Overall	55 (28.4)	140 (24.7)	1.53 (1.06, 2.23)	1.28 (1.02, 1.62)
Proximal	46 (23.7)	120 (21.2)	1.40 (0.91, 2.14)	1.18 (0.91, 1.54)
Distal	9 (4.6)	20 (3.5)	2.08 (1.01, 4.26)	1.85 (1.14, 3.01)

Logistic regression modeling used to estimate odds ratios and 95% CI for post-colonoscopy cancer over specified time intervals, adjusting for age, age, sex, site of cancer (proximal vs. distal), MMR status (deficient vs. proficient), stage (metastatic vs. not metastatic), and clinical center