Skip to main content
. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Hypertension. 2016 Oct 3;68(6):1483–1493. doi: 10.1161/HYPERTENSIONAHA.116.07747

Figure 2. AngII evokes a sustained, glutamate-mediated inward current in presympathetic PVN neurons.

Figure 2

A, Bath-applied AngII (0.5 μM) induced an inward shift in Iholding that was blocked by glutamate receptor antagonism. Note the outward shift beyond baseline evoked by glutamate receptor blockade. B, Representative current segments for each recording condition in A are shown at an expanded time scale. C, Summary data showing mean Iholding values (left) and changes in mean RSM noise level (right) in each recording condition (n= 7). D, Preincubation of slices with the AT1a receptor blocker losartan (10 μM) occluded AngII effects on Iholding and RSM noise (n=7). **P< 0.01 vs. ACSF and AP5+DNQX; #P< 0.05 vs. ACSF.