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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Hypertension. 2016 Oct 24;68(6):1459–1466. doi: 10.1161/HYPERTENSIONAHA.116.08261

Table 4.

Results of the meta-analysis of the associations between maternal mean arterial blood pressures and fetal imprinted gene SNP alleles that were used in the composite score in the Cambridge Baby Growth Study, the Cambridge Wellbeing Study and HAPO Study participants with European ancestry.

Gene Fetal SNP Parental Transmission Study n r Meta-analysis
r		 Meta-analysis
p
FAM99A rs1489945 maternal CBGS 277 0.102 −0.498 0.271
Wellbeing 61 0.345
HAPO 999 −0.970
DLK1 rs10139403 maternal CBGS 301 0.191 0.161 6.277×10−10
Wellbeing 47 0.017
HAPO 1,067 0.158
DLK1 rs12147008 maternal CBGS 306 0.228 0.299 0.044
Wellbeing 65 0.017
HAPO 1,099 0.560
H19 rs217222 paternal CBGS 325 0.114 0.056 0.314
Wellbeing 65 0.251
HAPO 1,149 −0.137
SNRPN rs1453556 paternal CBGS 300 0.216 0.121 0.024
Wellbeing 64 0.079
HAPO 1,016 0.060
IGF2, INS rs6356 paternal CBGS 387 0.139 0.214 5.965×10−6
Wellbeing 51 0.263
HAPO 1,020 0.259
NNAT rs6066671 paternal CBGS 395 0.103 0.199 0.006
Wellbeing 60 0.171
HAPO 986 0.295

CBGS = Cambridge Baby Growth Study, Wellbeing = Cambridge Wellbeing Study, HAPO = Hyperglycemia and Adverse Pregnancy Outcome Study. For the HAPO study the r-values were estimated from the standardised β-values using the method of Peterson & Brown23.