Figure 6. Role of AT₁ Receptors.

(A) AT_1aR mRNA expression in PVN (n=10 per group), RVLM (n=10 control, n=9 renin-b^Null), SFO (n=10 per group), ARC (n=9 per group) and NTS (n=9 control, n=10 renin-b^Null). *, P< 0.05 vs control. (B) Representative tracings of RSNA in chloralose-anesthetized mice before and during the 4^th hour following i.c.v. administration of leptin (5 μg). (C–D) Renal sympathetic nerve activity (SNA) response to i.c.v. injection of leptin. Percent changes in renal SNA for 4 hours after i.c.v. leptin are plotted and the last 60 minutes are summarized (control n=10, renin-b^Null n=5, renin-b^Null + i.c.v. losartan n=5). *, P<0.05 vs control; ^#, P<0.05 vs renin-b^Null without losartan.