Table 1.

Enzymatic PfCDPK4, PfCDPK1, TgCDPK1 and Src inhibition (IC₅₀) results. All results are the averages of at least three assays. N/T= not tested.

	Ar1	R2	IC50 (μM)
			PfCDPK4	PfCDPK1	TgCDPK1	Src
1			0.039 (±0.012)	0.115 (± 0.063)	0.002 (±0.0004)	1.32
2			0.031 (±0.003)	0.142 (± 0.011)	0.007 (±0.0003)	N/T
3			0.036 (±0.004)	0.114 (± 0.001)	0.002 (±0.001)	6.93
4			0.057 (±0.007)	1.128 (± 0.105)	0.005 (±0.003)	>30
5			0.074 (±0.033)	0.287 (± 0.048)	0.004 (±0.001)	7.27
6			0.037 (±0.005)	0.733 (± 0.082)	0.002 (±0.0003)	>30
7			0.058 (±0.022)	0.307 (± 0.071)	0.006 (±0.0007)	>10
8			0.082 (±0.021)	0.225 (± 0.028)	0.010 (±0.002)	4.75
9			0.075 (±0.015)	0.480 (± 0.183)	0.005 (±0.0009)	>10
10			0.083 (±0.030)	0.188 (± 0.085)	0.007 (±0.003)	10
11			0.094 (±0.042)	0.401 (± 0.100)	0.006 (±0.003)	N/T
12			0.077 (±0.043)	0.999 (± 0.429)	0.004 (±0.002)	0.98
13			0.082 (±0.006)	1.542 (± 0.354)	0.013 (±0.005)	>10
14			0.044 (±0.004)	0.496 (± 0.133)	0.008 (±0.003)	>10
15			0.102 (±0.033)	0.628	0.018 (± 0.009)	N/T
16			0.123 (±0.043)	0.916	0.014 (± 0.006)	N/T
17			0.081 (±0.011)	1.74 (± 0.331)	0.011 (± 0.002)	>10
18			0.113 (± 0.073)	>2	0.024 (± 0.016)	N/T
19			0.082 (± 0.003)	0.910 (± 0.145)	0.012 (± 0.002)	>10
20			0.090 (±0.031)	0.635 (± 0.048)	0.011 (± 0.002)	>10
21			0.094 (±0.040)	0.506 (± 0.078)	0.012 (± 0.007)	>10
22			0.079 (±0.032)	0.589 (± 0.107)	0.006 (± 0.002)	>10
23			0.048 (±0.013)	0.338 (± 0.062)	0.007 (± 0.002)	3.33
24			0.049 (± 0.020)	0.391 (± 0.026)	0.007 (± 0.003)	>10
25			0.103 (± 0.016)	0.468	0.009 (± 0.004)	10
26			0.094 (± 0.004)	0.478 (± 0.488)	0.006 (± 0.002)	>10
27			0.074 (± 0.023)	0.159 (± 0.051)	0.008 (± 0.002)	3.33
28			0.071 (± 0.008)	0.647 (± 0.244)	0.010 (± 0.002)	>10