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. Author manuscript; available in PMC: 2017 Aug 18.
Published in final edited form as: Cell Chem Biol. 2016 Aug 11;23(8):978–991. doi: 10.1016/j.chembiol.2016.06.016

Figure 3. Structural analysis of Inz-1 binding to cytochrome bc1.

Figure 3

A) Minimal Inhibitory Concentration (MIC) of Inz-1 for indicated cytochrome B mutants under respiratory growth conditions in S. cerevisiae. MIC’s were concordant from two independent experiments. B) Structure of yeast cytochrome B complex (PDB:1EZV) indicating location of Qi and Qo pockets. C) Structural alignment of yeast (PDB:1P84) and bovine (PDB:1SQV) cytochrome B showing Qo site and indicating location of two mutations that confer resistance to Inz-1. D) Computational docking of Inz-1 into Qo pocket of yeast cytochrome bc1 (PDB:1EZV) with location of resistance-conferring mutations overlaid.