Table 4.

Association between health service use and substance use (advanced prostate cancer cohort)

	Hospitalizations* OR (95% CI)	Outpatient Visits* OR (95% CI)	ER Visits* OR (95% CI)
Type of substance use disorder***
Age 66 - 74 years (adjusted for socio-demographic characteristics ,treatment, clinical characteristics and propensity score)
Alcohol dependence syndrome Drug psychoses and related Non-dependent use of drugs	2.0 (1.7, 2.5) 2.9 (2.3, 3.8) 1.6 (1.5, 1.7)	2.0 (1.3, 2.9) 3.2 (1.9, 5.2) 1.9 (1.7, 2.2)	1.3 (0.9, 1.9) 1.9 (1.3, 3.1) 1.5 (1.3, 1.7)
Age ≥ 75 years (adjusted for socio-demographic characteristics ,treatment, clinical characteristics and propensity score)
Alcohol dependence syndrome Drug psychoses and related Non-dependent use of drugs	1.5 (1.1, 2.2) 1.9 (1.4, 2.5) 1.6 (1.4, 1.9)	1.2 (0.7, 2.0) 1.9 (1.3, 2.8) 1.4 (1.1, 1.7)	0.9 (0.5, 1.9) 0.8 (0.5, 1.4) 1.6 (1.2, 2.1)
Period in which substance use disorder was identified ***
Age 66 - 74 years (adjusted for socio-demographic characteristics ,treatment, clinical characteristics and propensity score)
Pre prostate cancer diagnosis Cancer treatment phase Follow-up phase	1.4 (1.2, 1.6) 1.7 (1.5, 1.9) 1.9 (1.7, 2.1)	1.9 (1.5, 2.6) 2.1 (1.7, 2.6) 1.9 (1.6, 2.4)	1.1 (0.9, 1.5) 1.5 (1.3, 1.8) 1.8 (1.5, 2.1)
Age ≥ 75 years (adjusted for socio-demographic characteristics ,treatment, clinical characteristics and propensity score)
Pre prostate cancer diagnosis Cancer treatment phase Follow-up phase	1.5 (1.2, 1.8) 1.6 (1.3, 1.9) 1.9 (1.6, 2.5)	1.3 (0.9, 1.8) 1.4 (1.1, 1.8) 1.7 (1.3, 2.3)	1.2 (0.8, 1.9) 1.3 (0.9, 1.9) 1.5 (1.1, 2.3)

^*Negative binomial models