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. Author manuscript; available in PMC: 2016 Dec 16.
Published in final edited form as: J Med Genet. 2014 Oct 3;51(12):789–796. doi: 10.1136/jmedgenet-2014-102552

Table 2.

Diagnostic Test (2 by 2 tables) analysis for the identification of MLH1 mutation carriers

Sensitivity (95% CI) Specificity (95% CI)
Normal MLH1 promoter region 94.37% (86.20–98.44%) 87.67% (77.88–94.2%)
wt BRAF p.V600E 98.59% (92.4–99.96%) 65.75% (53.72–76.47%)
wt BRAF c.1799T>A p.Val600Glu OR Normal MLH1 promoter region 100% (94.94% to 100%) 63.01% (50.91% to 74.03%)
wt BRAF c.1799T>A p.Val600Glu AND Normal MLH1 promoter region 92.96% (84.33% to 97.67%) 90.41% (81.24% to 96.06%)