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MLH1 promoter region methylation in MLH1 mutation heterozygotes
| Sample number |
Level of methylation |
Clinical details | Family History | MLH1 Mutation |
|---|---|---|---|---|
| 11005300 | 29–38% | Carcinoma in situ in adenoma, aged 40 | Amsterdam | c.405insA |
| 11007868 | 19–60% | CRC aged 44 | Amsterdam | c.1852_1854delAAG p.Lys618del |
| 11007938 | 70–80% | CRC aged 53 | *FDR with endometrial cancer | MLH1 c.1668-1G>A r.spl? p.? |
| 11007944 | 67–82% | CRC aged 39 | Amsterdam | MLH1 del x6 |
First degree relative
