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. 2016 Dec 16;10:281. doi: 10.3389/fncel.2016.00281

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Copyright © 2016 Giordano, Costa, Lucchi, Leo, Brunel, Fehrentz, Martinez, Torsello and Biagini.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Electrocorticographic (ECoG) activity during seizures induced by 6-Hz corneal stimulation. EcoG traces obtained from frontal cortex of one out of three representative mice. Note that the trace clearly shows two components: (i) the ictal event corresponding to the motor component of the seizure; and (ii) the post-ictal event, characterized by flattening of basal activity corresponding to the non-motor component of seizures. Traces were respectively taken from a saline-treated mice (A) or an animal treated with EP-80317 (B). No quantification is provided because of the low number of animals per group (n = 3). RFC, right frontal cortex.