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. 2016 Dec 16;9:139. doi: 10.3389/fnmol.2016.00139

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Copyright © 2016 John and Mishra.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison and validation of galectins mRNA expression with protein profiling in mouse Basal ganglia, Ventricular Zone and Substantia nigra. (B,D,F) ABA based mRNA expression profile of 3 major galectins in the Striatal Caudoputamen (CP, site of activity dependent synaptic plasticity, motor control and procedural memory) region of the basal ganglia, Ventricular zone: VL (in the vicinity of neurogenic subventricular zone, SVG; and choroid plexus: chpl) and Substantia nigra (SN, motor control region) is compared with immunohistochemistry based protein expression in the respective regions as shown in (A,C,E). Pseudo-color calibration bar is included to represent the intensity of expression. Note a good regional corroboration between mRNA and protein expression except that the protein expression is more widespread due to the secretory nature. The protein is also detected in the extracellular space and on the surface of cells is suggestive of autocrine-paracrine effects.