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. 2016 Dec 6;5(12):e397. doi: 10.1038/mtna.2016.105

Figure 5.

Figure 5

Tumor-infiltrating CD11b+Ly6G+ neutrophils expressed high level of TNF-α and TGF-β in IDO shRNA treated mice. (a) Enriched CD11b+Ly6G+ neutrophils from tumor-infiltrated cells. (b) The mRNA expression of tumor-infiltrating neutrophils which was collected on day 16 post LLC1 injection. (c) Tumor volume at day 23. (d) The mRNA expression of tumor-infiltrating neutrophils which was collected at day 23 post LLC1 injection. * or **A statistically significant difference when compared with scramble IDO shRNA group (*P < 0.05; **P < 0.01). IDO, Indoleamine 2,3-dioxygenase; shRNA, short hairpin RNA; TGF-β, Transforming growth factor-β. TNF-α, tumor necrosis factor-α.