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. 2016 Dec 6;5(12):e397. doi: 10.1038/mtna.2016.105

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Copyright © 2016 Official journal of the American Society of Gene & Cell Therapy

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Neutrophils depletion abolished the antitumor effect of IDO shRNA. (a) Experimental design. 300 µg of anti-Ly6G antibody or IgG control was intraperitoneally injected at day 7, 10, and 14 after LLC1 cells injection. All mice were sacrificed at day 17. (b) Evaluation of depletion efficiency. The Ly6G⁺ cells were detected in total splenocytes after injection of depletion antibodies. (c) Tumor volume was measured at day 17. *A statistically significant difference between IgG and Ly6G groups (*P < 0.05). IDO, Indoleamine 2,3-dioxygenase; IgG, immunoglobulin G; shRNA, short hairpin RNA.