TABLE 1.
Mean survival times of Tga20 mice following intracerebral inoculation
The final dilutions of the ME7 and mBSE seeds in the “seed” samples were 1 × 10−15.
| Inoculum | Transmission rate (total deaths/total number) | Mean survival time ± S.D. |
|---|---|---|
| ME7 seed | % | days |
| Non-treated | 100 (6/6) | 133.8 ± 8.0 |
| Benzonase-treated | ||
| +PA | 100 (5/5) | 157.2 ± 16.0 |
| +HP | 100 (6/6) | 182.2 ± 27.5 |
| +HS | 100 (7/7) | 163.6 ± 15.6 |
| Non-additive | 0 (0/6) | >600 |
| mBSE seed | ||
| Non-treated | 100 (7/7) | 139.4 ± 4.5 |
| Benzonase-treated | ||
| +PA | 100 (6/6) | 135.7 ± 4.2 |
| +HP | 100 (7/7) | 196.1 ± 14.0 |
| +HS | 100 (6/6) | 188.3 ± 15.7 |
| Non-additive | 0 (0/5) | >600 |