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Etomidate and DS2 enhancement of [3H]muscimol binding to membrane-bound and purified α4β3δ GABAAR
Anesthetic modulation was calculated as the ratio (%) of specific [3H]muscimol binding (2 nm) in the presence versus the absence of modulator. The results are the means ± S.D. from three independent experiments.
| Compound | Concentration | Membrane-bound GABAAR | Purified GABAAR |
|---|---|---|---|
| μm | % | % | |
| Etomidate | 10 | 147 ± 28 | 129 ± 8 |
| DS2 | 30 | 139 ± 8 | 129 ± 14 |
