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. 2016 Sep 8;44(22):10619–10630. doi: 10.1093/nar/gkw801

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© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — Model for transcriptional interference at tgp1⁺ and pho1⁺ in S. pombe. (A) Reduced upstream lncRNA transcription corresponds with decreased nucleosome density over the tgp1⁺ and pho1⁺ promoters to permit expression of these phosphate response genes following phosphate-starvation. (B) In phosphate-replete conditions, lncRNA transcription upstream of tgp1⁺ and pho1⁺ results in transcription-coupled deposition of Set2-dependent H3K36me3 and recruitment of the Clr6 HDAC (Clr6CII). In addition, histone chaperones Spt6 and FACT travel with RNAPII and reorganize nucleosomes during lncRNA transcription in order to limit Pho7 transcription factor binding and suppress downstream gene expression.