Figure 10.

Schematic views of the T4 DNA replication complex with and without its protein components. (A) An ‘exploded’ two-dimensional view of the functional sub-assemblies of replication complex, specifically the polymerases, the helicase and the clamp-loader sub-assemblies, together with representative bound gp32 molecules and clusters (see text). (B) The same view, but here of the DNA framework of the replication complex with the proteins removed, in order to visualize the replication forks and p/t constructs within the overall complex to which gp32 can bind, and which are modeled, in part, by the ‘tailed’ DNA constructs used in this study and shown in Table 1.