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Comparative sequence analysis of duplex and G-quadruplex structures. (A) Chemical structures of G-C and A-T base pairs. (B) Hypothetical sequence alignment of an evolutionary conserved hairpin. Covariations in the alignment are shown in orange. (C) Chemical structure of a G-G-G-G tetrad. (D) Hypothetical sequence alignment of an evolutionary conserved G-quadruplex. Covariations in the alignment based on those identified in this work are shown in orange.
