Figure 2.
A set of hypothetical twitches generated using a Labview (National Instruments) program demonstrating the possible effects of altered calcium sensitivity on twitch kinetics. If the decrease in calcium sensitivity (increase in Kd) is primarily due to decreased kon, one would observe lower developed force (pink). If the decrease in calcium sensitivity is primarily due to increased koff, one would observe lower developed force and faster relaxation kinetics (gray). If the increase in calcium sensitivity (decrease in Kd) is primarily due to decreased koff, one would observe increased developed force and slower relaxation kinetics (dark blue). If the increase in calcium sensitivity (increase in Kd) is primarily due to increased kon, one would observe increased developed force and faster relaxation compared to the case where koff is decreased (green). Calcium transient (light blue) and original twitch (red) are also included in the figure.