Table 1. Multiple linear regression analysis of the association between change in brain volume and change in the peak intensity of the proteins whose changes were found to be significantly correlated with change in brain volume.

Beta = regression coefficient. The model is adjusted for the 5 randomization variables and MRI centre.

	m/z 15885 (0 to 25 months)		m/z 15141 (0 to 25 months)
	Beta (95% CI)	p	Beta (95% CI)	p
protein	0.83 (0.33, 1.33)	0.001	0.75 (0.29, 1.22)	0.002
treatment	-0·62 (-1.06, -0.19)	0.005	-0.60 (-1.03, -0.17)	0.007
	m/z 25110 (0 to 12 months)		m/z 25402 (0 to 12 months)
	Beta (95% CI)	p	Beta (95% CI)	p
protein	-0.99 (-1.72, -0.26)	0.008	-0.73 (-1.37, -0.09)	0.025
treatment	-0.26 (-0.56, -0.04)	0.090	-0.27 (-0.58, -0.04)	0.083