Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jan;23(1):23–31. doi: 10.1261/rna.058826.116

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2016 Mao et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

FIGURE 3. — Cortical neurogenesis defects of Casc3 compound mutants due to developmental delay. (A–P) E14.5 (A–L) and E13.5 (M–P) coronal sections of embryonic brains from control (A–D and M–P), Casc3^{RRU345/RRU345} (E–H), and Casc3^RRU345/Null (I–L), stained for PAX6+ radial glia (A,E,I,M), TBR2+ intermediate progenitors (B,F,J,N), TUJ1+ neurons (C,G,K,O), and CC3+ cells (D,H,L,P). Dotted lines denote boundaries of dorsal cortices. (Q–S) Quantification of dorsal cortical thickness (Q) percentage of all cells which are TBR2+ within a 200 µm column (R), and thickness of TUJ1+ layer relative to cortex (S) for indicated genotypes. For cortical thickness, the value of control brains was set to 1.0. (Q–S) Two-tailed Student's t-test, (*) P < 0.05, (n.s.) not significant. Error bars, SD. n = 3–4 biological replicates each. Scale bars: A–P, 50 µm.