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. 2017 Jan;23(1):98–107. doi: 10.1261/rna.058354.116

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© 2016 Yang et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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FIGURE 1. — (A) Domain organization of S. cerevisiae Pcf11, drawn with IBS (Liu et al. 2015). (B) Sequence alignment versus secondary structure for the C terminus of Pcf11 from S. cerevisiae to H. sapiens, drawn with ESPript (Robert and Gouet 2014). Conserved residues are indicated in black or in bold, based on similarity levels. Two putative zinc fingers and Clp1 interacting regions are highlighted in red boxes and a green box, respectively. Zinc coordinating Cys and His residues are highlighted in red boxes. Mutated residues Y575, E577, E578, and W582 are highlighted in yellow boxes.