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. 2017 Jan;24(1):55–58. doi: 10.1101/lm.044362.116

Figure 2.

Figure 2.

Pretraining and pretest infusion of muscimol in Au1 disrupt discriminatory threat condtioning. (A) Schematic outlining the discriminatory threat conditioning protocol. (B–D). Sites of vehicle (▪) and muscimol (▴) infusions for discriminatory threat conditioning experiments. Images modified and A/P values from Paxinos and Watson 6th ed. Red lines show the position of Au1. (E) Pretraining muscimol infusion in Au1 impairs discrimination of paired (CS+) and unpaired (CS−) tones (vehicle, n = 8; muscimol, n = 9; (**) P < 0.01). (F) Post-training muscimol infusion in primary auditory cortex does not affect discriminatory threat conditioning (vehicle, n = 6; muscimol, n = 5; (#) significant main effect for CS type, no significant main effect for drug, and no significant CS type × drug interaction). (G) Pretest infusion of muscimol in Au1 impairs auditory discrimination during the memory test (vehicle, n = 7; muscimol, n = 7). Au1, primary auditory cortex. Bars represent ± SEM.