Table 2. Psychiatric phenotype (ICD-10 diagnoses, Mini PAS-ADD thresholds and section history) for likely pathogenic and benign CNVs.
| Total in sample (%) n=202 | Likely pathogenic CNV group (%) n=22 | Likely benign CNV group (%) n=180 | |
|---|---|---|---|
| ICD-10 diagnosis | |||
| Psychosis | 49 (25%) | 3 (14%) | 46 (26%) |
| Bipolar disorder | 23 (11%) | 3 (14%) | 20 (11%) |
| Depressive episode | 62 (31%) | 4 (18%) | 58 (32%) |
| Other anxiety disorders | 45 (23%) | 2 (9%) | 43 (24%) |
| Hyperkinetic disorder | 21 (10%) | 3 (14%) | 18 (10%) |
| Pervasive developmental disorder | 68 (34%) | 8 (36%) | 60 (33%) |
| Mini PAS-ADD thresholds | |||
| Psychosis | 72 (36%) | 9 (41%) | 63 (35%) |
| Hypomania/mania | 33 (16%) | 5 (23%) | 28 (16%) |
| Depressive disorder | 76 (38%) | 5 (23%) | 71 (39%) |
| Anxiety disorder | 80 (40%) | 6 (27%) | 74 (41%) |
| Obsessive compulsive | 55 (27%) | 5 (23%) | 50 (28%) |
| Mental Health Act Section History | |||
| Previous history of involuntary admission | 45 (22%) | 7 (32%) | 38 (21%) |
| Forensic section | 21 (10%) | 6 (27%) | 15 (8%) |
ICD-10 diagnoses – the psychosis group was amalgamated to comprise: F20 schizophrenia, F25 schizoaffective disorder and F29 unspecified nonorganic psychosis. Other ICD-10 diagnoses reported independently are: F31 bipolar disorder, F32 depressive episode, F41 other anxiety disorders, F90 hyperkinetic disorder, F84 pervasive developmental disorder. Mini PAS-ADD thresholds – scores were calculated using standard guidelines, Mental Health Act (MHA) section – previous history of involuntary admission included previous and current MHA sections and forensic sections, forensic section – all individuals were on a forensic section at the time of recruitment no history of being on a forensic section was identified in any of the other participants. Note: several individuals had comorbid diagnoses and are included in more than one category.