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. 2016 Dec 16;6:39305. doi: 10.1038/srep39305

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Copyright © 2016, The Author(s)

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(a–c) Emphysematous phenotypes of WT and C57/BL6J-βENaC-Tg mice. Representative data of PAS and alcian blue-stained section of WT (a) (n = 9) and C57/BL6J-βENaC-Tg (b) (n = 11) mice. Square diameter, 300 μm. Quantitative morphometric analysis of alveolar septae of the lungs is shown in (c). (d–i) Respiratory parameters (resistance, elastance, compaliance, FVC, FEV0.1 and FEV0.1%) of WT (n = 15) and C57/BL6J-βENaC-Tg (n = 17) mice analyzed by flexiVent. ^**p < 0.01, ^***p < 0.001, versus WT; Student’s t test. (j,k) Correlation analysis of parameters. Summary of analysis between pulmonary parameters and biochemical parameters in BALF in WT and C57/BL6J-βENaC-Tg mice (n = 36–41) (j). ^*p < 0.05; Pearson’s correlation coefficient test. Correlation scatter plots of MLI and FEV0.1% (k).