Figure 3. Microarray analysis of lung mRNA of WT and in C57/BL6J-βENaC-Tg mice.
(a) A histogram representing the distribution of log2[ratio Cy3(C57/BL6J-βENaC-Tg)/Cy5 (WT)]. Number of genes up-regulated (log2[ratio Cy3/Cy5] ≥ 1.0) and down-regulated (log2[ratio Cy3/Cy5] ≤ −1.0) in lung tissue of C57/BL6J-βENaC-Tg mice is indicated. (b) Scatter plots based on raw values of significantly up-regulated and down-regulated meaningful genes in C57/BL6J-βENaC-Tg mice are indicated as closed circles (cut-off value was set). (c) Statistically significantly increased and decreased pathways in C57/BL6J-βENaC-Tg mice are listed.