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. 2016 Dec 16;6:39357. doi: 10.1038/srep39357

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Copyright © 2016, The Author(s)

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Overlay of ¹⁵N-¹H correlation spectra of wt (black) and concatenated HP0242 (red) before (A) and after 10 min of HDX (B). (C) Weighted chemical shift perturbation (CSP) resulting from concatenation as a function of residue number. CSP is defined as Δδ_N-H = [(Δδ_N)² + (Δδ_H/6.5)²]^1/2. (D) Structural mapping of the observed CSP onto the crystal structure of concatenated HP0242 (PDB entry: 3MLG) with the radius of the sausage representation being proportional to the size of CSP as indicated on the right hand side of the colour scale. The sites of concatenation are connected by dashed grey line.