. 2016 Dec 16;6:38707. doi: 10.1038/srep38707

Table 3. Summary of immune functions of free fatty acids.

	Previous studies	Lipidomic analysis in burn patients
SFA	➢Contribute to metabolic diseases (T2DM and obesity)¹⁰.➢Induces insulin resistance, ER stress, and inflammation²⁰,²⁵.	➢Correlate to greater age, burn severity, and mortality.➢May have anti-inflammatory roles (e.g. palmitate).
MuFA	➢Cardioprotective, reduces insulin resistance, and improves wound healing¹²,²⁸	➢Early mobilization may be physiological and beneficial.➢Persistent elevation correlated to increased mortality.
w-3 PuFA	➢Anti-inflammatory and immune resolution¹¹.➢Precursors to special pro-resolving mediators (SPM), i.e. resolvins³⁰.	➢Variable effect on inflammation.➢Pro-inflammatory responses from w-6 derivatives.
w-6 PuFA	➢Mediates inflammation and pain²⁹.➢Precursors to special pro-resolving mediators (SPM), i.e. lipoxins³⁰.	➢Anti-inflammatory effect potentially mediated via SPMs.➢Not necessary/sufficient for sepsis.