Table 1. Host iron-associated genes differentially regulated during P. aeruginosa infection.
| Gene name | Description | Fold up-regulated during infection | p-value |
|---|---|---|---|
| Lcn2 | Lipocalin 2 | 30.85 | 8.34E-04 |
| Ltf | Lactotransferrin | 14.34 | 2.16E-05 |
| Fth1 | Ferritin heavy chain 1 | 6.27 | 2.33E-03 |
| Cp | Ceruloplasmin | 4.82 | 2.83E-05 |
| Hba-a1 | Hemoglobin alpha, adult chain 1 | 2.11 | 3.12E-03 |
| Hba-a2 | Hemoglobin alpha, adult chain 2 | 2.96 | 3.03E-04 |
| Hbb-bs | Hemoglobin beta adult s chain | 2.07 | 1.98E-03 |
| Hbb-bt | Hemoglobin beta adult t chain | 2.54 | 1.89E-04 |
| Steap4 | Metalloreductase able to reduce Fe3+ to Fe2+ using NAD+ as receptor | 20.64 | 4.59E-05 |
| Slc39a14 | Soluble metal carrier protein | 17.85 | 2.69E-05 |
| Fbxl5 | F-box and leucin-rich repeat protein 5, iron sensor | 5.72 | 1.65E-05 |
| Picalm | Phosphatidylinositol binding clathri assembly protein, transferrin receptor internalization | 3.74 | 3.45E-05 |
| Scd2 | Stearoyl-coenzyme A desaturase 2, iron binding and oxydoreductase activity | −1.9 | 5.54E-05 |
| Mmp8 | Metallopeptidase 8 | 34.28 | 2.57E-05 |
| Mmp9 | Metallopeptidase 9 | 13.82 | 2.28E-05 |
Fold changes were calculated by comparing infected to non-infected mice. Fold changes greater than 1 indicate that the gene was up-regulated during infection compared to in vitro growth conditions. Fold changes inferior to −1 indicate that the gene was down-regulated during infection compared to in vitro growth conditions.