Table 2.
A. INDUCED_IMMEDIATELY
| BACH2, BATF2, CREM, CSRNP3, DACH1, EBF1, EGR1/2/3, FOS, FOXC1, GATA6, HES1, HEY1, HIC1, HIF1A, HOXD1/3/8/9/10/13, KDM5B(JARID1B), KLF12, LEF1, MAFB, NCOA3/7, NKX3-1, NR0B1, PBX1, PPARG/D, RARA, SMAD3, SOX4/8/9, TBX2/3, TEAD2, TLE3, TLX2, TULP4, ZFP2, ZNF71/135/436/606/641 | GO:000 3700 sequence-specific DNA binding transcription factor activity; GO:0006355 regulation of transcription, DNA-templated; GO:0030154 cell differentiation |
| AKR1C1/3, BCDO2, CRABP2, CYP26A1/B1, DHRS3, RARA, RBP1, RDH10, SDC4, SP100, STRA6, PPARD/G | GO:0001523 retinoid metabolic process; GO:0042573 retinoic acid metabolic process; GO:0001972 retinoic acid binding; GO:0032526 response to retinoic acid |
| BMP4, EGR1, GREM2, LEF1 | GO:0030509 BMP signaling pathway |
| DACT3, LEF1, PSEN1, SOX4 | GO:0016055 Wnt signaling pathway |
| FOXC1, HES1, HEY1, HIF1A, MDK, NCOR2, PSEN1, TLE3 | GO:0007219 Notch signaling pathway; GO:0005112 Notch binding |
| ERBB2, IRS2, KITLG, PDGFRA/B, SPRY2/4 | GO:0007173 epidermal growth factor receptor signaling |
| PDGFRA/B, PLAT | GO:0048008 platelet-derived growth factor receptor signaling pathway |
| NGFR, NTRK1, PCSK5, PLEKHG2, RALB, RIT1 | GO:0048011 neurotrophin TRK receptor signaling pathway; GO:0038180 nerve growth factor signaling pathway |
| DISP1 | GO:0007224 smoothened signaling pathway; GO:0008158 hedgehog receptor activity; GO:0009880 embryonic pattern specification |
| APC2, EML4, KIFAP3, LYST, NEIL2, SPTAN1 | GO:0015630 microtubule cytoskeleton |
| AHNAK, ARPC1B, AVIL, CORO2A, CTTNBP2NL, FAM129B, FGD4/6, FHL2, FLNB, KALRN, LCP1, MYRIP, PDLIM5/7, PPP1R12B, SYNPO/2, TRIOBP, VCL | GO:0015629 actin cytoskeleton |
| ARHGDIB, CLASP2, CNN2, LIMK1, NUAK2, PAK1, PALM, PFN2, PLK2, RND3, SDCBP, SOX9 | GO:0007010 cytoskeleton organization |
| CEACAM1, GAB2, ITGA1, ITGB8; ADD3, LIMK1, MYADM, MRCL3(MYL12A), TRIO | GO:0007229 integrin-mediated signaling pathway; GO:0005911 cell-cell junction; GO:0040011 locomotion; GO:0016477 cell migration |
| ANTXR1, ATP1B1, BVES, CALCA, CDH23, CEACAM1, CLSTN3, COL12A1, COMP, FBLIM1, KITLG, NCAM2, NEO1, PCDHB2/4/6/9-11/13/14, PPFIBP1, PSEN1, PVRL2, RET, RND3, SPP1, TGFB1I1, TPBG, TRO,VTN | GO:0007155 cell adhesion; GO:0007411 axon guidance |
| HIF1A, HTR2B, KITLG, LEF1, RET, SOX8 | GO:0001755 neural crest cell migration |
| EGR2/EGR3, ERBB2, SOX8 | GO:0007422 peripheral nervous system development |
| JARID1B, JARID2 | GO:0016568 chromatin modification; GO:0048863 stem cell differentiation |
| SLIT2, SLITRK6, FLOT1 | GO:0035385 Roundabout signaling pathway; GO:0050772 positive regulation of axonogenesis |
| EPHA2, EPHB3; SEMA6C, SEMA6D | GO:0048013 ephrin receptor signaling pathway; GO:0030215 semaphorin receptor binding; GO:0007411 axon guidance |
| DCX, DPYSL3, ERBB2, KCNQ2, PSEN1, PTPRO, RRAS, SPTAN1, ST8SIA4; STMN2, TEAD2 | GO:0007411 axon guidance; GO:0030426 growth cone; GO:0048666 neuron development |
| LAMB2, LAMC1 | GO:0005605 basal lamina; GO:0031175 neuron projection development |
| DLG2, GLS, GNG2/8, HCN1, KCNQ2, PANX, RRAS, SDCBP, SST, SYNJ2, SYT2; STX7, STXBP5/6 | GO:0007268 synaptic transmission; GO:0019905 syntaxin binding; GO:0045202 synapse |
| HTR2B, FOS,KALRN, NAB2, NAV2, DCX, RGS9, RTN4, VCL | GO:0007399 nervous system development; neurite branching; GO:0030334 regulation of cell migration |
| CDKL5 | GO:0001764 neuron migration; GO:0050773 regulation of dendrite development; GO:0051726 regulation of cell cycle |
| BCL2, BOK, CASP4/9, CTSB, NLRP1, SKIL; ANGPT1, CPEB4, CRLF1, F2R, HIF1A, MDK, NTRK1, PSEN1 | GO:0006915 apoptotic process; GO:0043524 negative regulation of neuron apoptotic process |
| ADAM12, ADAMTS9, MMP2/11 | GO:0008237 metallopeptidase activity |
| F2R, GALR1, GPR161, HTR2B, IGF2R, P2RY2, PTGER2, PTGIR | GO:0004930 G-protein coupled receptor activity; GO:0004966 galanin receptor activity; GO:0007218 neuropeptide signaling pathway; GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway |
| CRLF1 | GO:0005127 ciliary neurotrophic factor receptor binding |
The table displays exemplary the genes from the group A and their functional annotations. The group A contains genes that demonstrated immediate increase of expression in response to ATRA