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Changes of pathologic characteristics over the study period. Figure 2A: pathologic stage ≥pT3b. Figure 2B: pathologic Gleason score ≥8. Figure 2C: positive surgical margins. Figure 2D: lymph node invasion. Figure 2E: number of total (blue line) and positive (red line) lymph nodes removed. Figure 2F: specimen confined disease. Shaded area: 95% confidence interval.
