Table 2.
Pre-infusion, infusion, and post-infusion median values for physiologic, behavioural, and drug variables related to 85 adult patients with severe TBI sedated with dexmedetomidine
| Variable | Pre-infusion period in median (IQR) |
Infusion period in median (IQR) |
Post-infusion period in median (IQR) |
|---|---|---|---|
| SBP (mmHg) |
129.5 (117, 141) | 121 (111, 131.5) | 134.5 (120, 144) |
| DBP (mmHg) |
67 (60, 75) | 61.5 (55.5, 67) | 68 (60, 76.5) |
| MAP (mmHg) |
84 (78, 93) | 77 (71, 84.5) | 85 (77, 93) |
| HR (beats/min) |
91.5 (83, 103) | 89 (73, 97) | 95.5 (85.5, 102) |
| RASS | −2 (−2, −1) | −1 (−2, −1) | −1 (−2, 0) |
| GCS | 8 (7, 10) | 9.5 (7.5, 10) | 10 (8, 11) |
| Fentanyl equivalents (mcg/hr) |
59.10 (33.30, 92.85) | 23.00 (11.33, 59.20) | 15.10 (5.33, 62.00) |
| Propofol (mcg/hr) |
20.48 (1.31, 35.48) | 0.00 (0.00, 5.36) | 0.00 (0.00, 14.88) |
| Midazolam (mg/hr) |
0.42 (0.00, 1.08) | 0.08 (0.00, 0.31) | 0.21 (0.00, 1.38) |
Note: Propofol dosage is converted to dosage requirement for a standard 70 kg patient.