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. 2016 Oct 28;5(4):359–368. doi: 10.1080/21623945.2016.1252011

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© 2016 The Author(s). Published with license by Taylor & Francis

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 2. — BSCFAs inhibit lipolysis independent of PDE3B and PI3K in primary rat adipocytes. Lipolysis was measured after 1 hour of stimulation without (BASAL) or with 30 nM isoproterenol (ISO), in the absence (CTRL) or presence of 10 mM of isobutyric acid (I-BA), isovaleric acid (I-VA), acetic acid (AA) propionic acid (PA), butyric acid (BA) or insulin (INS) (1nM). The inhibitor for PDE3 (OPC3911) and the inhibitor for PI3K (Wortmannin;WM) were used in BASAL or ISO-stimulated lipolysis in the presence of the branched or non-branced SCFAs. A) I-BA, I-VA and INS in combination with OPC3911; B) I-BA, I-VA and INS in combination with WM; C) AA, PA, BA and INS in combination with WM. The values for I-BA, I-VA, AA, PA, BA and INS are related to CTRL (control without branched or non-branched SCFAs) in BASAL condition. For A-C, mean ± SD (n = 3) were used and significance levels were accepted when *p < 0.05, **p < 0.01 and ***p < 0.001.