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. 2016 Oct 13;3(6):e1242454. doi: 10.1080/23723556.2016.1242454

Figure 1.

Figure 1.

Molecular mechanisms through which RNF8 promotes tumor progression and chemoresistance. In non-cancerous cells (A), RNF8 positively regulates the DNA damage response. In contrast, overexpressed RNF8 in cancerous cells directly promotes the nuclear localization and protein stability of TWIST via K63-linked ubiquitination. In breast cancer patients (B), high expression of RNF8 correlates with tumor progression, conferring chemoresistance and promoting cancer metastasis. Ub, ubiquitination.