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Dual function of Suv39h1 in constitutive heterochromatin dynamics. Suv39h1 enhances HP1α sumoylation and promotes its targeting to pericentric domains independently of H3K9me3 (seeding step). Suv39h1 KMT activity promotes H3K9me3, providing binding sites for HP1α and ensuring H3K9me3-dependent maintenance of constitutive heterochromatin (propagation/maintenance step).
