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. 2004 Sep 1;32(15):4676–4686. doi: 10.1093/nar/gkh786

Figure 1.

Figure 1

The structure of the Xenopus SMRT cDNA. SMRT is a large corepressor of >2300 amino acids, which in the human genome is encoded by a gene consisting of 49 exons. The protein can be divided into an N-terminal region, which encodes three repressor domains (RD1–3) and two SANT domains between RD1 and RD2. Interaction domains ID-N and ID-C in the C-terminal part of the protein each contain a CoRNR box motif and mediate interaction with nuclear receptors. A third CoRNR box (diagonal bars) has been identified in SMRT located in ID-N at a similar position to CoRNR box-3 of NCoR (see text). The variable exons have been highlighted.