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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Ann Surg Oncol. 2016 Aug 15;23(12):3811–3821. doi: 10.1245/s10434-016-5446-2

Table 4.

Estimated treatment (margin threshold) effects on LR from the Bayesian network meta-analysis

Threshold distance for negative margins relative to positive: mean OR (95% CrI) adjusted for follow-up
>0 or 1 mm 2 mm 3 mm 10 mm
Main model (N patients) 2230 2412 289 1963
0.45 (0.32-0.61) 0.32 (0.21-0.48) 0.30 (0.12-0.76) 0.32 (0.19-0.49)
Sensitivity analysis (N patients) 1957 1851 272 1079
    WBRT cohorts only 0.45 (0.34-0.61) 0.33 (0.23-0.47) 0.22 (0.08-0.53) 0.37 (0.24-0.57)
Sensitivity analysis (N patients) 1781 1524 289 616
    Van Zee et al. excluded 0.43 (0.31-0.57) 0.29 (0.19-0.45) 0.32 (0.14-0.75) 0.27 (0.16-0.47)
Sensitivity analysis (N patients) 2692 2555 322c 2160
    Adding studies with no summary age dataa 0.44 (0.30-0.63) 0.31 (0.19-0.51) 0.32 (0.14-0.73) 0.20 (0.11-0.35)*
Adjustment for covariates (based on main model)
    Age 0.46 (0.33-0.63) 0.34 (0.22-0.51) 0.33 (0.13-0.83) 0.33 (0.20-0.51)
    Median recruitment year 0.45 (0.31-0.62) 0.31 (0.19-0.46) 0.29 (0.12-0.68) 0.32 (0.20-0.49)
    Proportion with radiotherapy 0.46 (0.33-0.63) 0.33 (0.22-0.49) 0.29 (0.12-0.74) 0.32 (0.20-0.50)
    Proportion with endocrine therapyb 0.45(0.29-0.70) 0.33 (0.18-0.57) 0.29(0.10-0.79) 0.31(0.17-0.57)
    Proportion with high grade DCISb 0.45 (0.32-0.62) 0.33 (0.21-0.48) 0.31(0.12-0.74) 0.39 (0.25-0.59)
*

95% CrI for ROR of 10 mm versus >0 or 1 mm did not cross 1.

a

These studies (from the meta-analysis by Wang et al.) were ineligible for inclusion in our meta-analysis because of lack of summary age data (see eligibility criteria); hence, sensitivity analysis reports estimates if these were included in models

b

Due to missing covariate information, these analyses were undertaken in a reduced number of studies (19 for endocrine therapy; 16 for high grade DCIS) therefore numbers analysed in these models will be less than those shown in main models. Alternative methods to deal with missing data produced similar results.

c

Two studies using a 5 mm threshold were included with the 3 mm threshold group.

Abbreviations: CrI = credible interval; DCIS = ductal carcinoma in situ; LR = local recurrence; mm = millimetre; OR = odds ratio; ROR = relative odds ratio; WBRT = whole-breast radiotherapy.