Table 1.
Presenting clinical characteristics of pediatric AMKL patients (n=153)
| Characteristics | CBFA2T3/GLIS2 (n = 24) | NUP98/KDM5A (n = 14) | KMT2A-r (n = 14) | RBM15/MKL1 (n = 18) | Monosomy 7 (n = 9) | Other (n = 74) | All (n = 153) |
|---|---|---|---|---|---|---|---|
| Median age, y (range) | 1.5 (0.5-4.0) | 1.9 (0.8-8.5) | 1.9 (0.7-12.0) | 0.7* (0.1-2.7) | 1.5 (0.5-17.1) | 1.6 (0.1-15.1) | 1.6 (0.1-17.1) |
| Median WBC count (range) | 17.3 × 109/L (7.5-300.1) | 14.0 × 109/L (5.8-188.0) | 7.4 × 109/L (1.1-31.0) | 13.8 × 109/L (5.6-32.7) | 14.5 × 109/L (8.7-90.2) | 14.4 × 109/L (1.1-378.5) | 13.7 × 109/L (1.1-378.5) |
| Male, % | 25 | 43 | 71 | 33 | 22 | 51 | 46 |
| Origin | |||||||
| AIEOP, % | 42 | 21 | 36 | 17 | 22 | 32 | 31 |
| DCOG/BFM/SLH, % | 17 | 50 | 36 | 28 | 33 | 29 | 29 |
| COG, % | 42 | 29 | 29 | 56 | 45 | 39 | 40 |
| HSCT | 11 (46%) | 4 (29%) | 9 (64%) | 9 (50%) | 5 (56%) | 30 (36%) | 63 (41%) |
| 4-y pEFS, % | 33 ± 10 | 36 ± 13 | 36 ± 13 | 59 ± 12 | 33 ± 16 | 62 ± 6 | 51 ± 4 |
| 4-y pOS, % | 38 ± 10 | 36 ± 13 | 36 ± 13 | 70 ± 11 | 33 ± 16 | 70 ± 5 | 56 ± 4 |
| 4-y pCIR, % | 42 ± 10 | 36 ± 14 | 50 ± 14 | 6 ± 6 | 33 ± 18 | 22 ± 5 | 29 ± 4 |
KMT2A-r, KMT2A rearrangement.
*
Significantly lower age at diagnosis (P = .038).