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. 2016 Dec 8;10:626. doi: 10.3389/fnhum.2016.00626

Table 2.

Evidence for mechanisms of PA at Level 3 of analysis.

Lead author Year Sample Mechanistic finding Type of mediation
Albinet 2016 36 older adults Improvements in cognition following a 21-week exercise intervention are independent of improvements in mood Experimental
Blumenthal 1989 101 older adults A 4-month exercise intervention improves mood symptoms in males, but does not show any clear pattern of improvements in cognition Experimental
Blumenthal 1991 101 older adults 4, 8, or 14 months of exercise training does not improve cognitive task performance Experimental
Emery 1998 73 Chronic Obstructive Pulmonary Disorder patients Exercise improves verbal fluency and reduces depressive symptoms compared to baseline scores and non-exercising groups Experimental
King 1997 43 older adults Improvements in self-rated sleep quality in exercising group following 16-week exercise intervention Statistical
Lichtman 1983 64 young and mid-life adults A 4-month exercise intervention improves performance on the Stroop Task Statistical
Madden 1989 85 older adults and 24 younger adults 4 or 8 months of exercise does not improve cognitive task performance Experimental
Robitaille 2014 470 older adults Social support and cognitive engagement mediate the effects of PA on cognition Statistical
Singh 1997 32 older adults Exercise improves self-rated sleep quality following a 10-week intervention Statistical
Vance 2005 158 older adults Sedentary behavior has significant indirect associations with neurocognitive functioning through depression and social support Statistical
Wilckens in press 109 adults (59 younger, 50 older) Sleep mediates the relationship between PA and executive functioning Statistical
Williams 1997 187 older women Exercise improves performance on tests of memory and processing speed following a 12-month intervention. Depression and anxiety symptoms decrease following the intervention for participants reporting the highest symptoms at baseline, though not differently from the non-exercising group. Experimental No group × Time interaction for mood outcomes