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. 2016 Sep 20;72(1):115–127. doi: 10.1093/jac/dkw381

Figure 4.

Figure 4.

AMP-resistant mutants are less susceptible to human defensins. (a) Susceptibility to the human α-defensins was determined by calculating percentage bacterial survival following 2 h of exposure to 10 μM peptide. Susceptibility to the human β-defensins (b) hBD1, (c) hBD2, (d) hBD3 and (e) hBD4 was determined as for α-defensins with 10 μM (hBD1, hBD2, hBD4) or 1 μM (hBD3) peptide concentrations. Limit of detection of the assay was 1% survival. Values given are the mean ± SEM derived from at least three independent determinations. Statistical significance relative to WT was determined by performing one-way ANOVA with Fisher's least significant difference test used for post hoc analysis on log-transformed data (***P < 0.001, **P < 0.01 or *P < 0.05).