Table 1.
Strain no. | Passaged with | Approximate no. of generationsa | MIC (mg/L)b |
|||
---|---|---|---|---|---|---|
LL-37 | WGH | PR-39 | CNY100HLc | |||
DA28823 | WT, no passage | none | 192 | 16 | 4 | 24 |
DA30560 | no peptide | 322 | 192 | 16 | 4 | 24 |
DA29677 | LL-37 | 189 | >512 | 64 | 4 | 48 |
DA29680 | LL-37 | 189 | >512 | 128 | 8 | 32 |
DA30557 | WGH | 322 | >512 | 192 | 12 | 48 |
DA30559 | WGH | 322 | >512 | 256 | 12 | 32 |
DA36424 | LL-37 and WGH | 210 | >512 | 192 | 12 | 32 |
DA35920 | PR-39 | 168 | >512 | 128 | 8 | 32 |
DA37296 | PR-39 | 168 | >512 | 96 | 8 | 32 |
aCalculated based on number of generations achieved in MIEM without peptide.
bMIC was determined in MIEM using the broth microdilution method.
cCNY100HL is a modified AMP derived from the human C3 complement peptide CNY21.28