Figure 1.

Estimated breast cancer incidence rates with combinations of breast cancer risk factors, Nurses’ Health Study, 1980–2010. Incidence is shown with all variables set to the observed mean (Total); all risk factors combined in Table 2 set to low risk (All); weight change since 18 years of age, alcohol consumption, physical activity level, breastfeeding, and menopausal hormone therapy (MHT) combined and all set to low risk (5-Modifiable); weight change since 18 years of age, alcohol consumption, and MHT combined and all set to low risk (3-Modifiable); and each individual risk factor set to low risk (Weight Change through MHT).