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. Author manuscript; available in PMC: 2017 Dec 6.
Published in final edited form as: Biochemistry. 2016 Nov 28;55(48):6718–6729. doi: 10.1021/acs.biochem.6b01014

Figure 5.

Figure 5

Ramachandran plot for the glycine-rich loop G302GGGY in wild-type and mutant HDAC8 enzymes. Symbols are defined in the key and colors are consistent with those in Figures 3 and 4: G302A HDAC8, blue; G303A HDAC8, orange; G304A HDAC8, brown; G305A HDAC8, yellow. Regions of the Ramachandran plot are indicated as follows: generally favored (dark blue), generally allowed (light blue), glycine favored (dark yellow), and glycine allowed (light yellow). Plot generated using RAMPAGE.43