Figure 2.

Random blood glucose and fasted plasma insulin are reduced in Srr KO mice. (A-B) Random (A) and 14-hour fasted (B) body weight (g) of adult Srr WT (white) and KO (black) female and male mice (n = 11–14). (C) Random blood glucose (mg/dL) from tail vein, sampled in the morning (n = 19–21). D: 14-hour fasted blood glucose (n = 11–13). (E) Random plasma insulin (ng/mL) from facial vein, determined by ELISA (n = 11–14). (E) 14-hour fasted plasma insulin showing a significant decrease in female Srr KO mice (n = 5–6). Mice were age-matched between genotypes across a range of 2–4 months. *p < 0.05, **p < 0.01, ***p < 0.001 by unpaired Student t-test.