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Half standard glucose attenuates hypoxia-induced release of lactate dehydrogenase (LDH). Hypoxia (2.8% oxygen for 5.5 h followed by re-oxygenation) increased the release of LDH from rat islets cultured continuously at 11 mM glucose (blue patterned bar). The release was attenuated in islets pre-cultured at 5.5 mM glucose (red patterned bar, *p < 0.03 for difference). Mean ± SEM of 8 experiments.
