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. 2016 Dec 22;1(21):e90240. doi: 10.1172/jci.insight.90240

Figure 3. β-Agonist promotes HIF-1α accumulation under normoxia.

Figure 3

(A) Expression of HIF-1α and Lamin B in HUVECs treated with diluent or isoproterenol (33–900 μM) for 2 hours (n = 3–6/condition). Data are mean ± SEM. (B) Expression of HIF-1α and Lamin B in HUVECs treated with 300 μM isoproterenol for 0.5 to 24 hours (n = 3–4/condition). Data are mean ± SD. (C) Expression of HIF-1α and Lamin B in HUVECs treated with beta 1 blocker CGP-20712A or beta 2 blocker ICI-118551 (1–1,000 nM) for 45 minutes, followed by 2-hour isoproterenol (n = 3). Data are mean ± SD. *P < 0.05; **P < 0.005; ***P < 0.0005, ANOVA.