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Increased fibrosis in Scn2b null right atrium. A. Masson’s trichrome staining shows increased fibrosis (blue) in null RA but not LA compared to WT. B. Quantification of fibrosis (P=0.002, Mann-Whitney Rank Sum Test). N=6 per genotype. C. Transition of atrial fibrillation to atrial flutter in null atrium. Increased levels of fibrosis are proposed to provide anchoring points for rotors underlying the transition.
